A Model-Based Assessment of the Seizure Onset Zone Predictive Power to Inform the Epileptogenic Zone.

ABSTRACT: Epilepsy surgery is a clinical procedure that aims to remove the brain tissue responsible for the emergence of seizures, the epileptogenic zone (EZ). It is preceded by an evaluation to determine the brain tissue that must be resected. The identification of the seizure onset zone (SOZ) from intracranial EEG recordings stands as one of the key proxies for the EZ. In this study we used computational models of epilepsy to assess to what extent the SOZ may or may not represent the EZ. We considered a set of different synthetic networks (e.g., regular, small-world, random, and scale-free networks) to represent large-scale brain networks and a phenomenological network model of seizure generation. In the model, the SOZ was inferred from the seizure likelihood (SL), a measure of the propensity of s

SUBMITTER: Lopes MA 

PROVIDER: S-EPMC6498870 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature