Identification of Potential Crucial Genes Associated With the Pathogenesis and Prognosis of Endometrial Cancer.

ABSTRACT:

Background and objective

Endometrial cancer (EC) is a common gynecological malignancy worldwide. Despite advances in the development of strategies for treating EC, prognosis of the disease remains unsatisfactory, especially for advanced EC. The aim of this study was to identify novel genes that can be used as potential biomarkers for identifying the prognosis of EC and to construct a novel risk stratification using these genes.

Methods and results

An mRNA sequencing dataset, corresponding survival data and expression profiling of an array of EC patients were obtained from The Cancer Genome Atlas and Gene Expression Omnibus, respectively. Common differentially expressed genes (DEGs) were identified based on sequencing and expression as given in the profiling dataset. Pathway

SUBMITTER: Liu L 

PROVIDER: S-EPMC6499025 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature