Non-invasive dural stimulation in mice: A novel preclinical model of migraine.

ABSTRACT: BACKGROUND:Migraine is characterized by a collection of neurological symptoms in the absence of injury or damage. However, several common preclinical migraine models require significant damage to the skull to stimulate the dura mater, the likely source of afferent signaling leading to head pain. The goal of this study was to determine whether dural stimulation can be performed in mice using an injection that does not cause injury or damage. METHODS:Using mice, injections of stimuli were administered to the dura mater through the soft tissue at the intersection between the lambdoidal and sagittal sutures. This technique did not require a permanent cannula nor did it cause damage to the skull or dura. Following injection of noxious stimuli, migraine-like behaviors were measured including cut

SUBMITTER: Burgos-Vega CC 

PROVIDER: S-EPMC6499065 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature