Ontology highlight
ABSTRACT:
SUBMITTER: He Y
PROVIDER: S-EPMC6499164 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Frontiers in pharmacology 20190411
Super-enhancers (SEs) refer to large clusters of enhancers that drive gene expressions. Recent data has provided novel insights in elucidating the roles of SEs in many diseases, including cancer. Many mechanisms involved in tumorigenesis and progression, ranging from internal gene mutation and rearrangement to external damage and inducement, have been demonstrated to be highly associated with SEs. Moreover, translocation, formation, deletion, or duplication of SEs themselves could lead to tumor ...[more]