Methodologic considerations for measuring energy expenditure differences between diets varying in carbohydrate using the doubly labeled water method.

ABSTRACT:

Background

Low-carbohydrate diets have been reported to significantly increase human energy expenditure when measured using doubly labeled water (DLW) but not by respiratory chambers. Although DLW may reveal true physiological differences undetected by respiratory chambers, an alternative possibility is that the expenditure differences resulted from failure to correctly estimate the respiratory quotient (RQ) used in the DLW calculations.

Objective

To examine energy expenditure differences between isocaloric diets varying widely in carbohydrate and to quantitatively compare DLW data with respiratory chamber and body composition measurements within an energy balance framework.

Design

DLW measurements were obtained during the final 2 wk of month-long baseline (BD; 50% ca

SUBMITTER: Hall KD 

PROVIDER: S-EPMC6499509 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature