Quantitative comparison of three rat models of Achilles tendon injury: A multidisciplinary approach.

ABSTRACT: The Achilles tendon, while the strongest and largest tendon in the body, is frequently injured. Inconclusive evidence exists regarding treatment strategies for both complete tears and partial tears. Well-characterized animal models of tendon injury are important for understanding physiological processes of tendon repair and testing potential therapeutics. Utilizing three distinct models of rat Achilles tendon injury, the objective of this study was to define and compare the effects and relative impact on tendon properties and ankle function of both tear severity (complete tear versus partial tear, both with post-operative immobilization) and immobilization after partial tear (partial tear with versus without immobilization). We hypothesized that a complete tear would cause inferior post-in

SUBMITTER: Huegel J 

PROVIDER: S-EPMC6499652 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature