Layer-specific arterial micromechanics and microstructure: Influences of age, anatomical location, and processing technique.

ABSTRACT: The importance of matrix micromechanics is increasingly recognized in cardiovascular research due to the intimate role they play in local vascular cell physiology. However, variations in micromechanics among arterial layers (i.e. intima, media, adventitia), as well as dependency on local matrix composition and/or structure, anatomical location or developmental stage remain largely unknown. This study determined layer-specific stiffness in elastic arteries, including the main pulmonary artery, ascending aorta, and carotid artery using atomic force indentation. To compare stiffness with age and frozen processing techniques, neonatal and adult pulmonary arteries were tested, while fresh (vibratomed) and frozen (cryotomed) tissues were tested from the adult aorta. Results revealed that the mea

SUBMITTER: Rafuse M 

PROVIDER: S-EPMC6499687 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature