Theobromine consumption does not improve fasting and postprandial vascular function in overweight and obese subjects.

ABSTRACT:

Backgound

Theobromine, a component of cocoa, may favorably affect conventional lipid-related cardiovascular risk markers, but effects on flow-mediated dilation (FMD) and other vascular function markers are not known.

Objective

To evaluate the effects of 4-week theobromine consumption (500 mg/day) on fasting and postprandial vascular function markers.

Design

In a randomized, double-blind crossover study, 44 apparently healthy overweight (N = 30) and obese (N = 14) men and women with low HDL-C concentrations, consumed daily 500 mg theobromine or placebo for 4 weeks. After 4 weeks, FMD, peripheral arterial tonometry (PAT), augmentation index (AIx), pulse wave velocity (PWV), blood pressure (BP) and retinal microvasculature measurements were performed. These measurements

SUBMITTER: Smolders L 

PROVIDER: S-EPMC6499748 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature