ALK4/5-dependent TGF-β signaling contributes to the crosstalk between neurons and microglia following axonal lesion.

ABSTRACT: Neuronal activity is closely influenced by glia, especially microglia which are the resident immune cells in the central nervous system (CNS). Microglia in medicinal leech are the only cells able to migrate to the injury site within the 24 hours post-lesion. The microglia-neuron interactions constitute an important mechanism as there is neither astrocyte nor oligodendrocyte in the leech CNS. Given that axonal sprouting is impaired when microglia recruitment is inhibited, the crosstalk between microglia and neurons plays a crucial role in neuroprotection. The present results show that neurons and microglia both use ALK4/5 (a type of TGF-β receptor) signaling in order to maintain mutual exchanges in an adult brain following an axonal injury. Indeed, a TGF-β family member (nGDF) is immediatel

SUBMITTER: Raffo-Romero A 

PROVIDER: S-EPMC6499822 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature