Uterine fluid proteome changes during diapause and resumption of embryo development in roe deer (Capreolus capreolus).

ABSTRACT: The uterine microenvironment during pre-implantation presents a pro-survival milieu and is essential for embryo elongation in ruminants. The European roe deer (Careolus capreolus) pre-implantation embryo development is characterised by a 4-month period of reduced development, embryonic diapause, after which the embryo rapidly elongates and implants. We investigated the uterine fluid proteome by label-free liquid chromatography tandem mass spectrometry at four defined stages covering the phase of reduced developmental pace (early diapause, mid-diapause and late diapause) and embryo elongation. We hypothesised that embryo development during diapause is halted by the lack of signals that support progression past the blastocyst stage. Three clusters of differentially abundant proteins were ide

SUBMITTER: van der Weijden VA 

PROVIDER: S-EPMC6499939 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature