Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis.

ABSTRACT:

Background

Recurrent respiratory papillomatosis (RRP) is a human papillomavirus (HPV)-driven disorder that causes substantial morbidity and can lead to fatal distal airway obstruction and post-obstructive pneumonias. Patients require frequent surgical debridement of disease, and no approved systemic adjuvant therapies exist.

Methods

A phase II study was conducted to investigate the clinical activity and safety of programmed death-ligand 1 (PD-L1) blockade with avelumab in patients with RRP.

Results

Twelve patients were treated. All patients with laryngeal RRP displayed improvement in disease burden, and 5 of 9 (56%) displayed partial responses. None of 4 patients with pulmonary RRP displayed a response. Using each patient's surgical history as their own control, patie

SUBMITTER: Allen CT 

PROVIDER: S-EPMC6500000 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature