Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews.

ABSTRACT:

Objective

To synthesise evidence from exclusively primary prevention data on the effectiveness of statins for prevention of cardiovascular disease (CVD), including stroke, and outcomes stratified by baseline risk and gender.

Design

Overview of systematic reviews (SRs) using Revised-AMSTAR approach to assess quality.

Data sources

Cochrane Database of Systematic Reviews, MEDLINE, Embase, PubMed, Scopus and PROSPERO to June 2017.

Eligibility criteria for selecting studies

SRs of randomised control trials (RCTs) or individual patient data (IPD) from RCTs, examining the effectiveness of statins versus placebo or no treatment on all-cause mortality, coronary heart disease, CVD (including stroke) and composite endpoints, with stratification by baseline risk and gender

SUBMITTER: Byrne P 

PROVIDER: S-EPMC6500096 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature