Hypoxia-inducible factors in CD4⁺ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity.

ABSTRACT: T cell help in humoral immunity includes interactions of B cells with activated extrafollicular CD4⁺ and follicular T helper (Tfh) cells. Each can promote antibody responses but Tfh cells play critical roles during germinal center (GC) reactions. After restimulation of their antigen receptor (TCR) by B cells, helper T cells act on B cells via CD40 ligand and secreted cytokines that guide Ig class switching. Hypoxia is a normal feature of GC, raising questions about molecular mechanisms governing the relationship between hypoxia response mechanisms and T cell help to antibody responses. Hypoxia-inducible factors (HIF) are prominent among mechanisms that mediate cellular responses to limited oxygen but also are induced by lymphocyte activation. We now show that loss of HIF-1α or o

SUBMITTER: Cho SH 

PROVIDER: S-EPMC6500120 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature