Chronic hepatitis B virus infection and total and cause-specific mortality: a prospective cohort study of 0.5 million people.

ABSTRACT:

Objectives

Chronic hepatitis B virus (HBV) infection is associated with a higher risk of liver diseases. Substantial uncertainty remains, however, about the associations of HBV infection with mortality from extrahepatic causes, especially from subtypes of cardiovascular diseases. We prospectively examined the association of chronic HBV infection with total and cause-specific mortality.

Design

Population-based prospective cohort study.

Setting

China Kadoorie Biobank in which participants from 10 geographically diverse areas across China were enrolled between 2004 and 2008.

Participants

475 801 participants 30-79 years of age without reporting major chronic diseases at baseline were enrolled. Hepatitis B surface antigen (HBsAg) was tested using an on-site rapid t

SUBMITTER: Si J 

PROVIDER: S-EPMC6500223 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature