Genetic components of human pain sensitivity: a protocol for a genome-wide association study of experimental pain in healthy volunteers.

ABSTRACT:

Introduction

Pain constitutes a major component of the global burden of diseases. Recent studies suggest a strong genetic contribution to pain susceptibility and severity. Whereas most of the available evidence relies on candidate gene association or linkage studies, research on the genetic basis of pain sensitivity using genome-wide association studies (GWAS) is still in its infancy. This protocol describes a proposed GWAS on genetic contributions to baseline pain sensitivity and nociceptive sensitisation in a sample of unrelated healthy individuals of mixed Latin American ancestry.

Methods and analysis

A GWAS on genetic contributions to pain sensitivity in the naïve state and following nociceptive sensitisation will be conducted in unrelated healthy individuals of mixed an

SUBMITTER: Schmid AB 

PROVIDER: S-EPMC6500241 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature