Empirical evidence of the impact of study characteristics on the performance of prediction models: a meta-epidemiological study.

ABSTRACT: OBJECTIVES:To empirically assess the relation between study characteristics and prognostic model performance in external validation studies of multivariable prognostic models. DESIGN:Meta-epidemiological study. DATA SOURCES AND STUDY SELECTION:On 16 October 2018, we searched electronic databases for systematic reviews of prognostic models. Reviews from non-overlapping clinical fields were selected if they reported common performance measures (either the concordance (c)-statistic or the ratio of observed over expected number of events (OE ratio)) from 10 or more validations of the same prognostic model. DATA EXTRACTION AND ANALYSES:Study design features, population characteristics, methods of predictor and outcome assessment, and the aforementioned performance measures were extracted from t

SUBMITTER: Damen JAAG 

PROVIDER: S-EPMC6500242 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature