AMBIsome Therapy Induction OptimisatioN (AMBITION): High dose AmBisome for cryptococcal meningitis induction therapy in sub-Saharan Africa: economic evaluation protocol for a randomised controlled trial-based equivalence study.

ABSTRACT:

Introduction

Cryptococcal meningitis is responsible for around 15% of all HIV-related deaths globally. Conventional treatment courses with amphotericin B require prolonged hospitalisation and are associated with multiple toxicities and poor outcomes. A phase II study has shown that a single high dose of liposomal amphotericin may be comparable to standard treatment. We propose a phase III clinical endpoint trial comparing single, high-dose liposomal amphotericin with the WHO recommended first-line treatment at six sites across five counties. An economic analysis is essential to support wide-scale implementation.

Methods and analysis

Country-specific economic evaluation tools will be developed across the five country settings. Details of patient and household out-of-pocket ex

SUBMITTER: Ponatshego PL 

PROVIDER: S-EPMC6500286 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature