Impact of ischaemic heart disease severity and age on risk of cardiovascular outcome in diabetes patients in Sweden: a nationwide observational study.

ABSTRACT:

Objectives

To compare short-term cardiovascular (CV) outcome in type 2 diabetes (T2D) patients without ischaemic heart disease (IHD), with IHD but no prior myocardial infarction (MI), and those with prior MI; and assess the impact on risk of age when initiating first-time glucose-lowering drug (GLD).

Design

Cohort study linking morbidity, mortality and medication data from Swedish national registries.

Participants

First-time users of GLD during 2007-2016.

Outcomes

Predicted cumulative incidence for the CV outcome (MI, stroke and CV mortality) was estimated. A Cox model was developed where age at GLD start and CV risk was modelled.

Results

260 070 first-time GLD users were included, 221 226 (85%) had no IHD, 16 294 (6%) had stable IHD-prior MI and 22 550

SUBMITTER: Jernberg T 

PROVIDER: S-EPMC6500345 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature