Predicting gene expression using DNA methylation in three human populations.

ABSTRACT:

Background

DNA methylation, an important epigenetic mark, is well known for its regulatory role in gene expression, especially the negative correlation in the promoter region. However, its correlation with gene expression across genome at human population level has not been well studied. In particular, it is unclear if genome-wide DNA methylation profile of an individual can predict her/his gene expression profile. Previous studies were mostly limited to association analyses between single CpG site methylation and gene expression. It is not known whether DNA methylation of a gene has enough prediction power to serve as a surrogate for gene expression in existing human study cohorts with DNA samples other than RNA samples.

Results

We examined DNA methylation in the gene regio

SUBMITTER: Zhong H 

PROVIDER: S-EPMC6500370 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature