High-Resolution Evolutionary Analysis of Within-Host Hepatitis C Virus Infection.

ABSTRACT:

Background

Despite recent breakthroughs in treatment of hepatitis C virus (HCV) infection, we have limited understanding of how virus diversity generated within individuals impacts the evolution and spread of HCV variants at the population scale. Addressing this gap is important for identifying the main sources of disease transmission and evaluating the risk of drug-resistance mutations emerging and disseminating in a population.

Methods

We have undertaken a high-resolution analysis of HCV within-host evolution from 4 individuals coinfected with human immunodeficiency virus 1 (HIV-1). We used long-read, deep-sequenced data of full-length HCV envelope glycoprotein, longitudinally sampled from acute to chronic HCV infection to investigate the underlying viral population and ev

SUBMITTER: Raghwani J 

PROVIDER: S-EPMC6500553 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature