African American ancestry contribution to asthma and atopic dermatitis.

ABSTRACT:

Objective

Asthma and atopic dermatitis (AD) are complex diseases with striking disparities across racial and ethnic groups, which may be partly attributable to genetic factors. Here we summarize current knowledge from asthma and AD genome-wide association studies (GWAS) and pharmacogenetic studies in African ancestry populations.

Data sources

GWAS catalog; PUBMed.

Study selections

GWAS catalog studies with trait annotations "asthma" and "atopic eczema" and African ancestry individuals in the discovery dataset; the recent CAAPA asthma GWAS; reports on pharmacogenetic studies in asthma and AD.

Results

Although GWASs have revolutionized gene discovery for multiple complex traits, African Americans continue to be severely underrepresented in sufficiently powered ge

SUBMITTER: Daya M 

PROVIDER: S-EPMC6500742 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature