Craniotomy and Survival for Primary Central Nervous System Lymphoma.

ABSTRACT: BACKGROUND:Cytoreductive surgery is considered controversial for primary central nervous system lymphoma (PCNSL). OBJECTIVE:To investigate survival following craniotomy or biopsy for PCNSL. METHODS:The National Cancer Database-Participant User File (NCDB, n = 8936), Surveillance, Epidemiology, and End Results Program (SEER, n = 4636), and an institutional series (IS, n = 132) were used. We retrospectively investigated the relationship between craniotomy, prognostic factors, and survival for PCNSL using case-control design. RESULTS:In NCDB, craniotomy was associated with increased median survival over biopsy (19.5 vs 11.0 mo), independent of subsequent radiation and chemotherapy (hazard ratio [HR] 0.80, P < .001). We found a similar trend with survival for craniotomy vs biopsy in the IS (HR

SUBMITTER: Rae AI 

PROVIDER: S-EPMC6500886 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature