Major Adverse Kidney Events in Pediatric Sepsis.

ABSTRACT:

Background and objectives

Major adverse kidney events, a composite of death, new kidney replacement therapy, or persistent kidney dysfunction, is a potential patient-centered outcome for clinical trials in sepsis-associated kidney injury. We sought to determine the incidence of major adverse kidney events within 30 days and validate this end point in pediatric sepsis.

Design, setting, participants, & measurements

We conducted a retrospective observational study using the Pediatric Health Information Systems Plus database of patients >6 months to <18 years old with a diagnosis of severe sepsis/septic shock; orders for bacterial blood culture, antibiotics, and at least one fluid bolus on hospital day 0/1; and known hospital disposition between January 2007 and December 2011. T

SUBMITTER: Weiss SL 

PROVIDER: S-EPMC6500940 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature