Serum and Urine Albumin and Response to Loop Diuretics in Heart Failure.

ABSTRACT:

Background and objectives

Diuretic resistance can limit successful decongestion of patients with heart failure. Because loop diuretics tightly bind albumin, low serum albumin and high urine albumin can theoretically limit diuretic delivery to the site of action. However, it is unknown if this represents a clinically relevant mechanism of diuretic resistance in human heart failure.

Design, setting, participants, & measurements

In total, 208 outpatients with heart failure at the Yale Transitional Care Center undergoing diuretic treatment were studied. Blood and urine chemistries were collected at baseline and 1.5 hours postdiuretic administration. Urine diuretic levels were normalized to urine creatinine and adjusted for diuretic dose administered, and diuretic efficiency was

SUBMITTER: Charokopos A 

PROVIDER: S-EPMC6500945 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature