DNA Methyltransferases in Malar Melasma and Their Modification by Sunscreen in Combination with 4% Niacinamide, 0.05% Retinoic Acid, or Placebo.

ABSTRACT:

Background

Malar melasma has a chronic and recurrent character that may be related to epigenetic changes.

Objective

To recognize the expression and DNA methylation of DNA methyltransferases (DNMTs) in malar melasma and perilesional skin, as well as the changes in DNMTs after their treatment with sunscreen in combination with 4% niacinamide, 0.05% retinoic acid, or placebo.

Methods

Thirty female patients were clinically evaluated for the expression of DNMT1 and DNMT3b using real-time PCR and immunofluorescence. These initial results were compared to results after eight weeks of treatment with sunscreen in combination with niacinamide, retinoic acid, or placebo.

Results

The relative expression of DNMT1 was significantly elevated in melasma compared with unaffecte

SUBMITTER: Campuzano-Garcia AE 

PROVIDER: S-EPMC6501269 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature