A quantitative in silico platform for simulating cytotoxic and nanoparticle drug delivery to solid tumours.

ABSTRACT: The role of tumour-host mechano-biology and the mechanisms involved in the delivery of anti-cancer drugs have been extensively studied using in vitro and in vivo models. A complementary approach is offered by in silico models, which can also potentially identify the main factors affecting the transport of tumour-targeting molecules. Here, we present a generalized three-dimensional in silico modelling framework of dynamic solid tumour growth, angiogenesis and drug delivery. Crucially, the model allows for drug properties-such as size and binding affinity-to be explicitly defined, hence facilitating investigation into the interaction between the changing tumour-host microenvironment and cytotoxic and nanoparticle drugs. We use the model to qualitatively recapitula

SUBMITTER: Wijeratne PA 

PROVIDER: S-EPMC6501342 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature