Metabolic characterization of the chitinolytic bacterium Serratia marcescens using a genome-scale metabolic model.

ABSTRACT:

Background

Serratia marcescens is a chitinolytic bacterium that can potentially be used for consolidated bioprocessing to convert chitin to value-added chemicals. Currently, S. marcescens is poorly characterized and studies on intracellular metabolic and regulatory mechanisms would expedite development of bioprocessing applications.

Results

In this study, our goal was to characterize the metabolic profile of S. marcescens to provide insight for metabolic engineering applications and fundamental biological studies. Hereby, we constructed a constraint-based genome-scale metabolic model (iSR929) including 929 genes, 1185 reactions and 1164 metabolites based on genomic annotation of S. marcescens Db11. The model was tested by comparing model predictions with experimental data an

SUBMITTER: Yan Q 

PROVIDER: S-EPMC6501404 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature