Local oxygen homeostasis during various neuronal network activity states in the mouse hippocampus.

ABSTRACT: Cortical information processing comprises various activity states emerging from timed synaptic excitation and inhibition. However, the underlying energy metabolism is widely unknown. We determined the cerebral metabolic rate of oxygen (CMRO₂) along a tissue depth of <0.3 mm in the hippocampal CA3 region during various network activities, including gamma oscillations and sharp wave-ripples that occur during wakefulness and sleep. These physiological states associate with sensory perception and memory formation, and critically depend on perisomatic GABA inhibition. Moreover, we modelled vascular oxygen delivery based on quantitative microvasculature analysis. (1) Local CMRO₂ was highest during gamma oscillations (3.4 mM/min), medium during sharp wave-ripples, asynchrono

SUBMITTER: Schneider J 

PROVIDER: S-EPMC6501513 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature