Molecular and Antigenic Properties of Mammalian Cell-Expressed Theileria parva Antigen Tp9.

ABSTRACT: East Coast Fever (ECF), caused by the tick-borne apicomplexan parasite Theileria parva, is a leading cause of morbidity and mortality in cattle of sub-Saharan Africa. The infection and treatment method (ITM) is currently the only vaccine available to control T. parva. Although ITM elicits levels of protection, its widespread adoption is limited by costs, laborious production process, and antibiotic co-treatment requirement, necessitating the development of a more sustainable vaccine. To this end, efforts have been concentrated in the identification of new T. parva vaccine antigens and in the development of suitable platforms for antigen expression. In this study, we investigated the molecular and antigenic properties of T. parva antigen Tp9 expressed by mammalia

SUBMITTER: Bastos RG 

PROVIDER: S-EPMC6501543 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature