Ontology highlight
ABSTRACT:
SUBMITTER: Nakahata Y
PROVIDER: S-EPMC6501775 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Nakahata Yasukazu Y Sahar Saurabh S Astarita Giuseppe G Kaluzova Milota M Sassone-Corsi Paolo P
Science (New York, N.Y.) 20090312 5927
Many metabolic and physiological processes display circadian oscillations. We have shown that the core circadian regulator, CLOCK, is a histone acetyltransferase whose activity is counterbalanced by the nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase SIRT1. Here we show that intracellular NAD+ levels cycle with a 24-hour rhythm, an oscillation driven by the circadian clock. CLOCK:BMAL1 regulates the circadian expression of NAMPT (nicotinamide phosphoribosyltransferase), an ...[more]