Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks.

ABSTRACT: Metabolic diseases are often characterized by circadian misalignment in different tissues, yet how altered coordination and communication among tissue clocks relate to specific pathogenic mechanisms remains largely unknown. Applying an integrated systems biology approach, we performed 24-hr metabolomics profiling of eight mouse tissues simultaneously. We present a temporal and spatial atlas of circadian metabolism in the context of systemic energy balance and under chronic nutrient stress (high-fat diet [HFD]). Comparative analysis reveals how the repertoires of tissue metabolism are linked and gated to specific temporal windows and how this highly specialized communication and coherence among tissue clocks is rewired by nutrient challenge. Overall, we illustrate how dynamic metabolic rela

SUBMITTER: Dyar KA 

PROVIDER: S-EPMC6501776 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature