Does bacterial vaginosis modify the effect of hormonal contraception on HIV seroconversion.

ABSTRACT:

Objectives

A recent study of HIV serodiscordant couples found that depot medroxyprogesterone acetate (DMPA) and oral contraceptive pills (OCPs) were associated with increased HIV risk in the presence, but not in the absence, of bacterial vaginosis. We assessed whether bacterial vaginosis is an effect modifier of the association between hormonal contraception and HIV seroconversion in female sex workers (FSWs) in Mombasa, Kenya.

Design

Prospective cohort study.

Methods

Data collected from HIV-negative FSWs from 1993 to 2017 were analyzed. Cox proportional hazards models were used to assess the relationship between HIV seroconversion and use of DMPA, OCPs, or hormonal contraceptive implants (Norplant, Jadelle).

Results

A total of 1985 women contributed 7127 perso

SUBMITTER: Sabo MC 

PROVIDER: S-EPMC6501800 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature