Association of an HDL Apolipoproteomic Score With Coronary Atherosclerosis and Cardiovascular Death.

ABSTRACT:

Background

Concentrations of circulating apolipoproteins are strongly linked to risk for coronary artery disease (CAD). The relative importance of the additional knowledge of apolipoprotein concentrations within specific lipoprotein species for CAD risk prediction is limited.

Objectives

This study sought to evaluate the performance of a high-density lipoprotein (HDL) apolipoproteomic score, based on targeted mass spectrometry of HDL-associated apolipoproteins, for the detection of angiographic CAD and outcomes.

Methods

HDL-associated apolipoprotein (apo) A-1, apoC-1, apoC-2, apoC-3, and apoC-4 were measured in 943 participants without prevalent myocardial infarction (MI) referred for coronary angiography in the CASABLANCA (Catheter Sampled Blood Archive in Cardiovascu

SUBMITTER: Natarajan P 

PROVIDER: S-EPMC6501819 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature