PATJ Low Frequency Variants Are Associated With Worse Ischemic Stroke Functional Outcome.

ABSTRACT:

Rationale

Ischemic stroke is among the leading causes of adult disability. Part of the variability in functional outcome after stroke has been attributed to genetic factors but no locus has been consistently associated with stroke outcome.

Objective

Our aim was to identify genetic loci influencing the recovery process using accurate phenotyping to produce the largest GWAS (genome-wide association study) in ischemic stroke recovery to date.

Methods and results

A 12-cohort, 2-phase (discovery-replication and joint) meta-analysis of GWAS included anterior-territory and previously independent ischemic stroke cases. Functional outcome was recorded using 3-month modified Rankin Scale. Analyses were adjusted for confounders such as discharge National Institutes of Health Str

SUBMITTER: Mola-Caminal M 

PROVIDER: S-EPMC6501820 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature