Dynamic Kinetic Resolution of Aldehydes by Hydroacylation.

ABSTRACT: We report a dynamic kinetic resolution (DKR) of chiral 4-pentenals by olefin hydroacylation. A primary amine racemizes the aldehyde substrate via enamine formation and hydrolysis. Then, a cationic rhodium catalyst promotes hydroacylation to generate α,γ-disubstituted cyclopentanones with high enantio- and diastereoselectivities.

SUBMITTER: Chen Z 

PROVIDER: S-EPMC6501835 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature