Significant Strain Variation in the Mutation Spectra of Inbred Laboratory Mice.

ABSTRACT: Mutation provides the ultimate source of all new alleles in populations, including variants that cause disease and fuel adaptation. Recent whole genome sequencing studies have uncovered variation in the mutation rate among individuals and differences in the relative frequency of specific nucleotide changes (the mutation spectrum) between populations. Although parental age is a major driver of differences in overall mutation rate among individuals, the causes of variation in the mutation spectrum remain less well understood. Here, I use high-quality whole genome sequences from 29 inbred laboratory mouse strains to explore the root causes of strain variation in the mutation spectrum. My analysis leverages the unique, mosaic patterns of genetic relatedness among inbred mouse strains to identi

SUBMITTER: Dumont BL 

PROVIDER: S-EPMC6501876 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature