Diagnostic Performance of T2Candida Among ICU Patients With Risk Factors for Invasive Candidiasis.

ABSTRACT:

Background

Invasive candidiasis (IC) comprises candidemia and deep-seated candidiasis. Blood culture (BC) is the gold standard test, but sensitivity is low. T2Candida is a new diagnostic test. We investigated the performance of T2Candida, BC, and Candida mannan antigen (MAg) for detection of IC in a high-risk intensive care unit (ICU) population.

Methods

One-hundred twenty-six ICU patients at high risk of IC with sepsis despite 3 days of broad-spectrum antibiotics were included. Paired BC, T2Candida, and MAg were obtained twice weekly (334 sets). Patients were classified into proven, likely, possible, or unlikely IC based on patient record review.

Results

At enrollment, 92 (77%) patients were receiving antifungal therapy (mainly fluconazole 66%). Fifteen (11.9%

SUBMITTER: Arendrup MC 

PROVIDER: S-EPMC6501878 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature