Lipoprotein(a) plasma levels, bone mineral density and risk of hip fracture: a post hoc analysis of the Women's Health Initiative, USA.

ABSTRACT:

Objectives

Elevated Lipoprotein(a) (Lp[a]) is a well-known risk factor for cardiovascular disease. However, its roles in bone metabolism and fracture risk are unclear. We therefore investigated whether plasma Lp(a) levels were associated with bone mineral density (BMD) and incident hip fractures in a large cohort of postmenopausal women.

Design

Post hoc analysis of data from the Women's Health Initiative (WHI), USA.

Setting

40 clinical centres in the USA.

Participants

The current analytical cohort consisted of 9698 white, postmenopausal women enrolled in the WHI, a national prospective study investigating determinants of chronic diseases including heart disease, breast and colorectal cancers and osteoporotic fractures among postmenopausal women. Recruitment for

SUBMITTER: Haring B 

PROVIDER: S-EPMC6501983 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature