Effects of esmolol on QTc interval changes during tracheal intubation: a systematic review.

ABSTRACT:

Introduction and aims

Esmolol is an ultra-short-acting β₁ antagonist that has been shown to attenuate the corrected QT (QTc) interval prolongation associated with laryngoscopy and endotracheal intubation (LTI). Prolongation of the QTc interval can precipitate arrhythmias, the most serious of which is torsades de pointes . The aim of this systematic review was to compare esmolol and placebo on QTc changes occurring during LTI.

Materials and methods

PubMed, EMBASE, Cochrane Registry of Clinical Trials and CINAHL databases (up to August 2018) were screened for randomised controlled trials comparing esmolol and placebo on QTc changes during LTI in cardiac and non-cardiac surgeries. The primary outcome was QTc changes during LTI and secondary outcome was related to adv

SUBMITTER: Thiruvenkatarajan V 

PROVIDER: S-EPMC6501987 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature