Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data.

ABSTRACT: Sex differences in the incidence and outcome of human disease are broadly recognized but, in most cases, not sufficiently understood to enable sex-specific approaches to treatment. Glioblastoma (GBM), the most common malignant brain tumor, provides a case in point. Despite well-established differences in incidence and emerging indications of differences in outcome, there are few insights that distinguish male and female GBM at the molecular level or allow specific targeting of these biological differences. Here, using a quantitative imaging-based measure of response, we found that standard therapy is more effective in female compared with male patients with GBM. We then applied a computational algorithm to linked GBM transcriptome and outcome data and identified sex-specific molecular subt

SUBMITTER: Yang W 

PROVIDER: S-EPMC6502224 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature