Dynamical modelling of secondary metabolism and metabolic switches in Streptomyces xiamenensis 318.

ABSTRACT: The production of secondary metabolites, while important for bioengineering purposes, presents a paradox in itself. Though widely existing in plants and bacteria, they have no definite physiological roles. Yet in both native habitats and laboratories, their production appears robust and follows apparent metabolic switches. We show in this work that the enzyme-catalysed process may improve the metabolic stability of the cells. The latter can be responsible for the overall metabolic behaviours such as dynamic metabolic landscape, metabolic switches and robustness, which can in turn affect the genetic formation of the organism in question. Mangrove-derived Streptomyces xiamenensis 318, with a relatively compact genome for secondary metabolism, is used as a model organism in our investi

SUBMITTER: Zhu XM 

PROVIDER: S-EPMC6502367 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature