Trajectories of psychosocial and cognitive functioning in pediatric patients with brain tumors treated with radiation therapy.

ABSTRACT:

Background

Pediatric patients with brain tumors who are treated with radiation therapy (RT) are at risk for neurocognitive and psychosocial late effects. Research to date has primarily examined these outcomes at a group level and in isolation. Advanced statistical techniques allow for person-centered analyses, as well as examination of relationships between domain-specific trajectories.

Methods

Patients with brain tumors (craniopharyngioma, ependymoma, low-grade astrocytoma, high-grade astrocytoma) were enrolled on a phase II clinical trial of RT. Three hundred and fifty patients completed serial neurocognitive assessments as part of their treatment monitoring, including pre-RT baseline, 6 months post-RT, and then yearly for 5 years. This secondary analysis focused on outcom

SUBMITTER: Willard VW 

PROVIDER: S-EPMC6502488 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature