Chronic Ethanol Exposure and Withdrawal Impair Synaptic GABA_A Receptor-Mediated Neurotransmission in Deep-Layer Prefrontal Cortex.

ABSTRACT:

Background

The prefrontal cortex (PFC) acts as an integrative hub for the processing of cortical and subcortical input into meaningful efferent signaling, permitting complex associative behaviors. PFC dysfunction is consistently observed with ethanol (EtOH) dependence and is a core component of the pathology of alcohol use disorders in current models of addiction. While intracortical gamma-aminobutryric acid (GABA)ergic neurotransmission is understood to be essential for maintaining coordinated network activity within the cortex, relatively little is known regarding functional GABAergic adaptations in PFC during EtOH dependence.

Methods

In the present study, male and female (> postnatal day 60) Sprague-Dawley rats were administered EtOH (5.0 g/kg; intragastric gavage) for 14

SUBMITTER: Hughes BA 

PROVIDER: S-EPMC6502689 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature