Periodicity, repression, and the molecular architecture of the mammalian circadian clock.

ABSTRACT: Large molecular machines regulate daily cycles of transcriptional activity and help generate rhythmic behavior. In recent years, structural and biochemical analyses have elucidated a number of principles guiding the interactions of proteins that form the basis of circadian timing. In its simplest form, the circadian clock is composed of a transcription/translation feedback loop. However, this description elides a complicated process of activator recruitment, chromatin decompaction, recruitment of coactivators, expression of repressors, formation of a repressive complex, repression of the activators, and ultimately degradation of the repressors and reinitiation of the cycle. Understanding the core principles underlying the clock requires careful examination of molecular and even atomic leve

SUBMITTER: Rosensweig C 

PROVIDER: S-EPMC6502704 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature