The effect of antioxidants in acute amitriptyline poisoning.

ABSTRACT:

Objective

To study the effect of Antioxidants supplementation in reducing oxidative stress induced in acute amitriptyline poisoning cases.

Design and methods

We compared the effect of supplementation of treatment of acute amitriptyline poisoning cases with alpha lipoic acid alone or with vitamin C, with that of those receiving only routine standard treatment (RST) as a control group.A total of 132 subjects divided into 5 groups were selected from IMCU (Intensive Medical Care Unit) and Toxicology Ward, Govt. General Hospital, Chennai, India. The study was restricted to grade 1 coma in poisoned subjects per the Edinburg scale. Each of the subjects was in the groups were supplemented with either placebo, RST, RST with vitamin C, RST with ALA, or RST with vitamin C and ALA.Acute

SUBMITTER: Kadar Ali SH 

PROVIDER: S-EPMC6502734 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature