Effect of Physical Activity on Plasma PCSK9 in Subjects With High Risk for Type 2 Diabetes.

ABSTRACT:

Background

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a liver serine protease regulating LDL cholesterol metabolism. PCSK9 binds to LDL receptors and guides them to lysosomes for degradation, thus increasing the amount of circulating LDL cholesterol. The aim of the study was to investigate associations between physical activity and plasma PCSK9 in subjects with high risk for type 2 diabetes (T2D).

Methods

Sixty-eight subjects from both genders with a high risk for T2D were included to a randomized controlled trial with a 3-month physical activity intervention. Physical activity intensities and frequencies were monitored throughout the intervention using a hip worn portable accelerometer. The plasma was collected before and after intervention for analysis of PCS

SUBMITTER: Makela KA 

PROVIDER: S-EPMC6502968 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature