Genetic analysis of pharmacogenomic VIP variants in the Blang population from Yunnan Province of China.

ABSTRACT:

Background

Genetic polymorphisms in numerous pharmacogenetics studies were regarded as the essential factors involved in the response to or metabolism of drugs. These genetic variants called very important pharmacogenetic (VIP) variants played a role in drugs metabolism, which have been summarized in the PharmGKB database. In this study, we genotyped 80 VIP variants from the PharmGKB in 100 members of Blang volunteers from Yunnan province.

Methods

Based on the PharmGKB database, we genotyped 80 VIP variants loci located in 47 genes. We used χ² tests to evaluate the significant loci between Blang and the other populations, including ASW, CEU, CHB, CHD, GIH, JPT, LWK, MEX, MKK, TSI, and YRI. The global variation distribution of the significant variants was observed

SUBMITTER: Zhang C 

PROVIDER: S-EPMC6503013 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature