Quantitative CEST imaging of amide proton transfer in acute ischaemic stroke.

ABSTRACT:

Background

Amide proton transfer (APT) imaging may help identify the ischaemic penumbra in stroke patients, the classical definition of which is a region of tissue around the ischaemic core that is hypoperfused and metabolically stressed. Given the potential of APT imaging to complement existing imaging techniques to provide clinically-relevant information, there is a need to develop analysis techniques that deliver a robust and repeatable APT metric. The challenge to accurate quantification of an APT metric has been the heterogeneous in-vivo environment of human tissue, which exhibits several confounding magnetisation transfer effects including spectrally-asymmetric nuclear Overhauser effects (NOEs). The recent literature has introduced various model-free and model-based approache

SUBMITTER: Msayib Y 

PROVIDER: S-EPMC6503165 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature