Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder: A Mendelian Randomization Study.

ABSTRACT:

Importance

There is a well-established negative association of educational attainment (EA) and other traits related to cognitive ability with posttraumatic stress disorder (PTSD), but the underlying mechanisms are poorly understood.

Objectives

To investigate the association of PTSD with traits related to EA.

Design, setting, and participants

Genetic correlation, polygenic risk scoring, and mendelian randomization (MR) were conducted including 23 185 individuals with PTSD and 151 309 control participants from the Psychiatric Genomics Consortium for PTSD and up to 1 131 881 individuals assessed for EA and related traits from UK Biobank, 23andMe, and the Social Science Genetic Association Consortium. Data were analyzed from July 3 through November 19, 2018.

Main outco

SUBMITTER: Polimanti R 

PROVIDER: S-EPMC6503495 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature