Assessment of Molecular Subtypes in Thyrotoxic Periodic Paralysis and Graves Disease Among Chinese Han Adults: A Population-Based Genome-Wide Association Study.

ABSTRACT:

Importance

Thyrotoxic periodic paralysis (TPP) is a potentially lethal complication of hyperthyroidism. However, only 1 specific susceptibility locus for TPP has been identified. Additional genetic determinants should be detected so that a prediction model can be constructed.

Objective

To investigate the genetic architecture of TPP and distinguish TPP from Graves disease cohorts.

Design, setting, and participants

This population-based case-control study used a 2-stage genome-wide association study to investigate the risk loci of TPP and weighted genetic risk score to construct a TPP prediction model with data from a Chinese Han population recruited in hospitals in China from March 2003 to December 2015. The analysis was conducted from November 2014 to August 2016.

SUBMITTER: Zhao SX 

PROVIDER: S-EPMC6503496 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature